Romanian/English Version: NAC in endometrioza – studii si experienta mea/NAC in endometriosis – 4 studies and my experience

NAC (N-acetil-cisteina) este un derivat de amino acid folosit de catre organism pentru a creste cantitatea de antioxidanti. Beneficiile acestei substante sunt recunoscute, fiind administrat atat de medicii alopati, cat si de nutritionisti (detoxul ficatului si beneficiile la nivel pulmonar sunt cele mai mentionate). Mai multe despre beneficiile NAC in general, pentru organism, puteti citi in linkurile din resurse (1).

Ce este cu atat mai interesant, insa, este faptul ca, in ultimii ani, cercetatorii au demarat mai multe studii pentru a testa eficienta NAC in contextul endometriozei.

Iata mai jos rezultatele a 4 studii care au incercat sa stabileasca in ce masura NAC poate fi vazut ca un tratament eficient in tinerea sub control a endometriozei si experienta mea cu acest supliment.

Inainte de toate, insa, tineti minte ca studiile de mai jos reprezinta doar o mica parte din munca de cercetare efectuata in acest moment. Acestea nu garanteaza vindecarea si nu inlocuieste consultul medicului specialist.

Studiu 1:

Combinatia de N-acetil cisteina, acid alfa lipoic si bromelaina are importante proprietati anti inflamatoare in contextul endometriozei in modele in vitro si in vivo

Specialistii din Italia au dorit sa evalueze eficienta asociatiei N-acetil cistena, acid alfa lipic si bromelaina in tratamentul endometriozei. Astfel, ei au explorat efectele antiinflamatorii si proapoptotice in cadrul unui studiu realizat pe soareci (s-au implantat fragmente de chisturi endometriozice umane intraperitoneal, iar una dintre cele doua grupe a primit tratamentul de mai sus, iar cealalta un alt tratament neutru).

La final, datele au aratat ca soarecii care primisera combinatia de NAC, ALA si Bromelaina prezentau un numar mai mic de chisturi, de dimensiuni mai mici, comparativ cu soarecii netratati.

Mai multe despre acest studiu, aici: https://www.ncbi.nlm.nih.gov/pubmed/25960622

Studiu 2:

O speranta in tratamentul endometriozei: un studiu observational, privind reducerea endometrioamelor ovariene, sub administrarea de NAC (N-acetil cisteina)

Specialistii din Italia au demarat un alt studiu observational pentru endometrioza ovariana. De asta data, cercetatorii au avut ca subiecti 92 de paciente diagnosticate cu endometrioza ovariana ( confirmata prin ecografie).

NAC a fost administrat pacientele per os timp de 3 luni, dupa urmatorul program: 600 mg, de trei ori pe zi, trei zile consecutive ale saptamanii.

Dupa 3 luni, diametrul chisturilor era putin redus in cadrul grupului caruia i se administra NAC (-1.5cm), versus o crestere considerabila in cadrul grupului netratat (+6.6 mm).

In plus, in timpul tratamentului cu NAC, s-au redus mai multe chisturi si au aparut mai putine chisturi ovariene.

In cadrul primului grup, care a primit NAC, au aparut 8 sarcini, iar in cadrul celuilalt, au aparut 6 sarcini.

Specialistii italieni cred ca NAC ar putea reprezenta un tratament eficient pentru endometrioza, fara efecte adverse, potrivit si pacientelor care isi doresc o sarcina.

Mai multe despre acest studiu, aici: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662115/

NAC2

Studiu 3:

Mai mult decat un antioxidant: N-acetil cisteina si endometrioza, intr-un studiu realizat pe soareci

Specialistii de la National Research Council, Roma Italia au realizat un studiu in model murin (pe soareci), pentru a vedea in ce masura NAC este benefic in contextul endometriozei.

Ei au concluzionat ca NAC exercita o actiune complexa asupra celulelor endometriale, implicand reglarea expresiei genelor si activitatea proteinelor, avand ca rezultat o proliferare scazuta a celulelor si un efect antiinflamator.

Tinand seama si de lipsa efectelor secundare, inclusiv neafectarea potentialului de fertilitate, specialistii italieni sustin ca NAC ar putea fi un tratament eficient pentru endometrioza.

Mai multe despre acest studiu, aici: https://www.ncbi.nlm.nih.gov/pubmed/20655527

Studiu 4:

Combinatia de NAC si L-Carnitina ar putea fi benefica pentru imbunatatirea atat a fertilitatii naturale, cat si a rezultatelor fertilizarii in vitro, la pacientele cu endometrioza usoara.

Studiul respectiv, aici: https://www.ncbi.nlm.nih.gov/pubmed/26342050

Experienta mea cu NAC:

Am inceput sa iau NAC in 2014, daca nu ma insel. E adevarat ca inainte de 2016, anul celei de-a doua operatii, starea mea era, probabil, prea grava pentru a fi ameliorata considerabil doar cu NAC. Dupa operatia din 2016, insa, am continuat sa iau NAC si m-am simtit foarte bine si, mai important, fara recidiva (asta insemanand ca nu am mai avut nodul, iar chisturile care au mai aparut pe parcurs s-au reabsorbit singure, de la sine sau cu ajutorul a ceea ce luam si faceam intre timp). In toti acesti ani, am avut perioade in care nu am tolerat foarte bine NAC, experimentand diverse simptome. Poate ca organismul meu nu reusea sa se detoxifice cum trebuie sau poate ca de vina era intestinul (ambele teorii pe care le-am gasit apoi cautand posibilele cauze).

Daca experimentati aceleasi probleme, incercati “trucurile acestea:

– impartiti doza de 1800 mg in trei (asta e protocolul unuia dintre studiile de mai sus: 1800 mg pe zi, 3 zile consecutive pe saptamana – asadar, ar trebui 1 capsula de 600 mg de 3 ori pe zi), luati pastila dupa masa, beti 2 litri de apa, fiti atente la intolerantele alimentare si eliminati, cel putin pentru un timp, acele alimente).

Avand in vedere cate studii s-au facut (cu concluzii imbucuratoare) si faptul ca o lunga perioada am reusit sa il iau (si nu am avut recidiva), consider ca este unul dintre suplimentele de top in endometrioza.

Bineinteles, va repet, nu inainte de a intreba un medic si nu fara a evalua situatia voastra foarte bine alaturi de un medic cu competente in diagnosticarea si tratarea endomotriozei (o sa repet aceste ultime cuvinte pana cand fiecare tara va avea cel putin astfel de specialisti).

un articol de Marina Rasnoveanu

Daca vreti sa cititi si alte materiale despre endometrioza si un stil de viata sanatos, urmariti-mi blogul si pe Facebook sau Instagram.

English Version: NAC (N-acetil-cisteina) in endometriosis – 4 studies and my experience

EN: NAC (N-acetyl-cysteine) is a kind of amino acid used by the body to build antoxidants. The benefits of this substance are well known, being recommended by doctors and naturopaths also. More about its benefits for our health you can read in the links for Resource section. (1)

What is even more interesting is the fact that in the past years, researchers have started a lot of studies to test NAC efficiency in endometriosis.

Here are the results of 4 studies I have found over the years, studies that tried to conclude on what extend NAC can be an efficient treatment for managing endometriosis. Besides this, you will also find my experience with this supplement.

Before we begin, I should tell you once more that all these studies are just a small part of the researching work done till the present time. Therefore, these does not guarantee curing and do not replace the consult of a doctor with experience in diagnosing and treating endometriosis.

Study 1

The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.

Conclusion: Finally, the novel mouse model allowed us to demonstrate that mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size, compared to untreated mice. Our findings suggest that these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis.

More, here: https://www.ncbi.nlm.nih.gov/pubmed/25960622

Study 2:

A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine

Conclusion: In conclusion, with reference to the unmet medical needs of endometriosis, our results clearly show that, by targeting various molecular and biochemical pathways involved in the initiation and maintenance of this disease, NAC effectively treats ovarian endometriosis. In terms of reduction in cysts size, our data are even more favorable than those granted by the currently adopted hormonal treatments, with the further advantages of fertility preservation and of the virtual absence of undesired side effects. The low cost of this natural drug can also be of interest for public health institutions.

More, here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662115/

NAC3

Study 3:

More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis.

Conclusion: N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment.

More, here: https://www.ncbi.nlm.nih.gov/pubmed/20655527

Study 4:

N-Acetyl-Cysteine and l-Carnitine Prevent Meiotic Oocyte Damage Induced by Follicular Fluid From Infertile Women With Mild Endometriosis.

Conclusion: Therefore, FF from infertile women with ME causes meiotic abnormalities in bovine oocytes, and, for the first time, we demonstrated that the use of NAC and LC prevents these damages. Our findings elucidate part of the pathogenic mechanisms involved in infertility associated with ME and open perspectives for further studies investigating whether the use of LC could improve the natural fertility and/or the results of in vitro fertilization of women with ME.

More, here: https://www.ncbi.nlm.nih.gov/pubmed/26342050

My experience with NAC:

I have been using NAC on and off since 2014. It is true that before 2016 my condition was way too worse to be managed only by NAC. After my 2016 surgery, I continued taking it and I felt very well and, most importantly, I had no reccurance. In all these years, I had periods when I couldn’t tolerate NAC very well, with different symptoms, from dry throat to breast pain. Maybe my body couldn’t detoxify well or maybe my gut was not as healthy as it should have been (both are theories I have found when researching potential reasons for that).

If you experience similar problems, try these “trips and tricks”:

– split de dose (according to one of the studies above the protocol is 1800 mg a day, three consecutives days, for 3 months and then 3 months break). So, split de 1800 mg dose into 3 (1 capsule of 600 mg 3 times a day).
– took the pill after a meal.
– drink at least 2 litres of water
– be careful with food intolerance and eliminate, at least for a while, the food that make you sick.

With all these studies and their promising conclusions and the fact that I have been taking it for some years and I do not have reccurance (meaning I don’t have a nodule anymore and the cysts that I have had in this period of 3 years have come and go by their own), I would say NAC is one of the most important supplements in endometriosis.

Of course, I repeat myself, don’t take it before asking a doctor (it is not a plant, so doctors should know about it) and not without your situation being evaluated by a good exicion surgeon, with experience in diagnosing and treating endometriosis (I will repeat this few last words till in each and every country will be at least 10 such specialists).

an article by Marina Rasnoveanu

Resources:

(1): https://www.webmd.com/vitamins-and-supplements/n-acetyl-cysteine-uses-and-risks

Do you want to read more articles about endometriosis and tips&tricks about a healthy lifestyle, follow my blog on Facebook and Instagram too.

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